Nicotine Nasal Spray
Nicotine nasal spray is a form of NRT that delivers nicotine in a mist that is absorbed in the nasal passages.
Users self-administer the product through the nose by inserting the spray tip into one nostril and then pointing the top towards the back of the nose before pressing firmly and quickly.
Maximum recommended dosage for adults: 64 sprays per daily (Nicorette Nasal Spray).
Clinical use of the nicotine nasal spray (FDA approved)
- Appropriate as a first-line medication for treating tobacco use.
and side effects
(see FDA package
- Pregnancy â€“ Pregnant smokers should be encouraged to quit without
medication. The nasal spray has not been shown to be effective
for treating tobacco dependence in pregnant smokers. (Nicotine
nasal spray is an FDA pregnancy Class D agent.) It has
has not been evaluated in breastfeeding patients.
- Cardiovascular diseases â€“ NRT is not an independent risk factor for
acute myocardial events. NRT should be used with caution among
particular cardiovascular patient groups: those in the immediate
(within 2 weeks) postmyocardial infarction period, those with serious
arrhythmias, and those with unstable angina pectoris.
- Nasal/airway reactions â€“ Some 94% of users report moderate to severe
nasal irritation in the first 2 days of use; 81% still reported nasal
irritation after 3 weeks, although rated severity typically was mild to
moderate. Nasal congestion and transient changes in sense of smell
and taste also were reported. Should not be
used in persons with severe reactive airway disease.
- Dependency â€“ Nicotine nasal spray produces higher peak nicotine
levels than other NRTs and has the highest dependence potential.
Approximately 15â€“20% of patients report using the active spray
for longer periods than recommended (6â€“12 months); 5% used the
spray at a higher dose than recommended.
- A dose consists of one 0.5-mg dose delivered
to each nostril (1 mg total). Initial dosing should be 1â€“2 doses per
hour, increasing as needed for symptom relief. Minimum recommended
treatment is 8 doses/day, with a maximum limit of 40
doses/day (5 doses/hour). Each bottle contains approximately 100
doses. Recommended duration of therapy is 3â€“6 months.
- Dosing information â€“ Patients should not sniff, swallow, or inhale
through the nose while administering doses, as this increases irritating
effects. The spray is best delivered with the head tilted slightly
- $49 per bottle (quantity used determines how long supply lasts)
|Source: Treating Tobacco Use and Dependence: 2008 Update. (Fiore et al, 2008)|
aCost data were established by averaging the retail price of the medication at national chain pharmacies
in Atlanta, GA, Los Angeles, CA, Milwaukee, WI , Sunnyside, NY, and listed online during
January 2008 and may not reflect discounts available to health plans and others.
Fiore MC, JaÃ©n CR, Baker TB, et al. Treating Tobacco Use and Dependence: 2008 Update. Clinical Practice Guideline. Rockville, MD: U.S. Department of Health and Human Services. Public Health Service. May 2008.
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